Background information on blood and blood donation Wound closure The platelets (or thrombocytes) and the proteins (clotting factors) in plasma protect the body from blood loss in the event of a minor injury.The cessation of bleeding involves multiple steps: The steps involved in the cessation of bleeding:The injured blood vessels tighten, they constrict.Platelets stick to the edge of the tear in the vessel, plugging it within just a few minutes.Coagulation factors (plasma proteins) are activated and, in a complex process, long strands of an insoluble protein called fibrin are formed.The fibrin reinforces the platelet plug, which shields the wound, enabling it to heal. Further Articles Transport of substances Continue to article Transport of substances Distribution of heat Continue to article Distribution of heat